Endocrine Abstracts

Background: The insulin tolerance test (ITT) is considered the gold standard test for evaluating the ACTH–cortisol axis in patients with pituitary disease. However, the test requires time and personnel resources, and has clear contraindications. Therefore, an ACTH stimulation test is often performed instead.Objective: The objective was to compare the cortisol response acquired by ACTH stimulation and during ITT in patients with pituitary disease.</p...

Background: Anti-Müllerian hormone (AMH) has a positive linear relationship to antral follicle count (AFC) in healthy women. However, studies of intra-follicular AMH-levels indicate a non-linear relation to AFC. It is speculated whether high AMH in polycystic ovary syndrome (PCOS) women is due to overactive follicles rather than directly reflect AFC.Study design: We used data from a previous case–control study, including 262 women with prior te...

Objective: In acromegaly, high GH/IGF1 levels are associated with abnormal glucose metabolism. Treatment with somatostatin analogues (SSAs) reduces the GH and IFG-1 levels. However, SSAs may worsen glucose homeostasis despite this, due to concomitant inhibition of insulin secretion. We studied the possible association between biochemical cure and glucose homeostasis in de novo patients with acromegaly.Design: Post hoc analysis from a ra...

Objective: Early postoperative results for the Preoperative Octreotide Treatment of Acromegaly (POTA) study has been published, and like later randomized studies we demonstrated a beneficial effect of presurgical treatment with somatostatin analogues (SSA) in GH-secreting macroadenomas when evaluated 3–4 months postoperatively. However, concerns about a potential lingering effect of SSA and thereby potential false positive results have been raised. The objective of this s...